Arizona Cardinals vs San Francisco 49ers NFL Projections

Week 3 • ARI vs SF • Updated 7:20 PM EDT

PregameInjury and inactive updates pending

Arizona Cardinals at San Francisco 49ers in Week 3: kickoff, team score and game total outlook, and the receivers to watch in this matchup.

Players in this matchup

Quarterbacks

Running backs

Receiving

Defense & special teams

DST

Arizona Cardinals D/ST

Arizona Cardinals

DST

San Francisco 49ers D/ST

San Francisco 49ers

Projected scores, totals, receiving lines and fantasy points for every matchup on this slate.

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How to read these NFL projections

EdgeRanked’s pregame model combines team scoring with passing, rushing, receiving and team-defense outcomes, using the personnel and matchup information available when the update was built. Targets describe receiving opportunity; receptions, yards and touchdowns describe different receiving outcomes. A game total combines both teams’ scoring outcomes. Every update carries a stage and a timestamp, so you can tell an early-week outlook apart from a later pregame refresh.

Team scores, game totals and WR and TE fantasy outputs are available now. Quarterback, running back, defense and special teams outputs, along with margin and receiving numbers, are marked limited confidence this early in the season. A label describes how settled a number is, not a guarantee of accuracy, and a pregame estimate is never an actual game result.

Last updated . If personnel news lands after an update, that matchup is marked as awaiting a refresh until the next one is published.

NFL projection questions

Which week does this page cover?

Week 3 of the 2026 season, with 16 games in the current slate. Today’s games are identified using Eastern time.

When were these projections updated?

The current pregame update was published on Sep 22, 2026 · 07:20 PM EDT. Preliminary numbers can still change as injury and inactive news becomes final.

What can I see without signing in?

Matchups, kickoff times, player names, team and opponent context, and which outlooks are ready for the week. Full numeric projections come with premium access.

How should I use the position and fantasy pages?

Start with the matchup and its update status, then open the relevant position page for quarterbacks, running backs, receivers, tight ends or team defenses. The fantasy board ranks every covered position together and can be filtered by position or team. Defense and special teams outlooks cover points allowed, sacks and takeaways; touchdowns scored by a defense are not part of the projection.